Self-destroying cancer cells: a major breakthrough for medical research

Self-destroying cancer cells: a major breakthrough for medical research: "Self-destroying cancer cells: a major breakthrough for medical research


Although cancer treatments have improved significantly over recent years, the search for the holy grail --a really effective cure -- remains elusive. Even the much improved treatments in common use today carry risks. As Dr Claus Jacob of the University of Exeter explains, 'cancer therapy has long been based on highly toxic substances that randomly kill healthy and sick cells alike.'

Now, however, Dr Jacob and Dr Gutowski of the Royal Devon and Exeter Hospital, with support from the Peninsula Medical School, are working on a new approach that causes cancer cells to self-destroy: effectively to commit suicide. In a project that started in 2000 (first with funding from the UK Research Council funding, then from the Leverhulme Trust and involvement of Exeter Antioxidant Therapeutics Ltd) the research has led to the discovery of catalysts that mimic the activity of a certain human enzyme (glutathione peroxidase). They work by setting off reactions in the cancer cells causing them to kill themselves. A crucial benefit of this approach is that the drugs target only diseased cells, leaving healthy ones intact. This means that any therapy based on this approach should avoid many of the risks and side effects associated with chemotherapy and radiotherapy. The treatment is also highly efficient because, as Dr Jacob says, 'catalysts are not consumed during their activity but are recycled over and over again. This means that only minute quantities of biocatalyst are needed to kill cancer cells.'

Dr Jacob goes on to explain that the principle to make cancer cells kill themselves 'is based on the fact that catalysts are not only effective, but also"